What is the thymidylate synthase gene?
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Mucositis and Rectum Cancer. Among its related pathways are Cell Cycle, Mitotic and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and mRNA binding.
What is the function of thymidylate synthase?
Thymidylate synthase plays a central role in the biosynthesis of thymidylate, an essential precursor for DNA biosynthesis. In addition to its role in catalysis and cellular metabolism, studies from our laboratory have shown that thymidylate synthase functions as an RNA binding protein.
What is tyms?
Thymidylate synthase (TYMS) is an important target for chemotherapy drugs, such as 5-fluorouracil (5FU) and methotrexate. Over-expression of TYMS is linked to resistance to TYMS-targeted chemotherapy drugs.
What is the product of thymidylate synthase?
Thymidylate synthase (TS) (EC 2.1. 1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA.
Which of the following drugs is inhibiting the enzyme thymidylate synthase?
Trifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis.
Is thymidylate a monophosphate?
Thymidine monophosphate (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA.
How is thymidylate derived?
Thymidylate Is Derived from dCDP and dUMP In bacteria, the pathway to dUMP begins with formation of dUTP, either by deamination of dCTP or by phosphorylation of dUDP (Fig. 21-36). The dUTP is converted to dUMP by a dUTPase.
What is a full form of TYMS?
An acronym used in texting. Means “thank you so much”
What is the substrate of thymidylate synthase?
In the proposed mechanism, TS forms a covalent bond to the substrate dUMP through a 1,4-addition involving a cysteine nucleophile. The substrate tetrahydrofolate donates a methyl group to the alpha carbon while reducing the new methyl on dUMP to form dTMP.
Which one is the thymidylate synthase inhibitor?
Which is a potent inhibitor of thymidylate synthase?
The antipyrimidine drug, 5-fluorouracil (5-FU), as its active metabolite, FdUMP, is a potent inhibitor of thymidylate synthase (TS), and this is generally considered to be its primary mechanism of action (Pratt et al., 1994).